V600E mutations in full length BRAF are seen in a small percentage of PA (6%) [9,12–14]; however, they are much more common in grade II, and high grade malignant pediatric gliomas; accounting for 18% of grade II, 33% of grade III, and 18% of grade IV tumors (23% grades II-IV) [15]. The gene discussed is BRAF; the disease is glioma.