We found that intracranial infection of newborn N-TVA/Ink4a/Arflox/lox mice with RCASBP(A) viruses containing BRAF-FLVE, KRASG12D or gain of function MEK (MEKGF) in combination with Cre leads to the development of high grade gliomas of various subtypes and morphologies [16,27]. Here, CDKN2A is linked to central nervous system cancer.