This is evidenced by the markedly reduced levels of resistin-leptin, thus amplifying insulin and C-peptide hormones (Table 5). T. crispa treatment has lowered the secretion of insulin hormones in HFDTC rats compared to rats in NC group, countering the hyperinsulinemia effects which is the main characteristic of insulin resistance [4, 5, 16]. This evidence concerns the gene LEP and Hyperinsulinemia.