These studies revealed that 177 of the 2497 lncRNAs in rat cerebral cortex showed increased binding to either Sin3A or coREST following ischemia, and that of these, 26 lncRNAs enriched with Sin3A and 11 lncRNAs enriched with coREST were upregulated by ischemia. The gene discussed is RCOR1; the disease is ischemia.