The direct effects of tumour-derived AQP1 expression on tumour growth have been demonstrated in other models: melanoma cells transfected with AQP1 showed increased growth and, in an in vivo model of melanoma, AQP1 blockade or inoculation of melanoma into AQP1-deficient mice slowed tumour growth by limiting vascular supply [22, 23]. This evidence concerns the gene AQP1 and neoplasm.