MYH6 and myocarditis: These T cell findings were unexpected since α-MyHC only constitutes a small fraction (7–10 %) of the total MyHC in human heart tissue, and challenged longstanding notions based on myocarditis models in mice (in which α-MyHC constitutes >90 % of the total cardiac MyHC) that the immune targeting of α-MyHC was due to its cardiac abundance, and stimulated efforts to define alternative mechanisms.