HIF1A and neoplasm: In light of the high expression levels of both HIF-1α and ILK in PC-3 cells relative to the other cell lines examined and the sensitivity of PC-3 xenograft tumors to ILK inhibition [19], the PC-3 xenograft tumor model was selected to assess the ability of T315 to disrupt the HIF-1α-ILK regulatory loop in vivo.