In light of the tumor suppressor role of Foxo3a [32], this transcriptional repression of Foxo3a is consistent with the reported function of YB-1 in protecting tumor cells from apoptosis by acting as a transcriptional repressor of the tumor suppressor gene p53 [46] and the cell death-associated gene Fas [47]. The gene discussed is ENSG00000279284; the disease is neoplasm.