HIF1A and neoplasm: This tumor suppression was associated with decreased intratumoral expression of HIF-1α and ILK, accompanied by parallel decreases in the phosphorylation/expression levels of ILK's downstream targets (Akt, mTOR, GSK3β), as well as increased epithelial (Foxo3a, E-cadherin) and decreased mesenchymal (YB-1, vimentin, Snail, Zeb1) markers (Figure 7B and 7C).