Regarding the other three SNPs, rs12150053 (c.-5736T>C), rs12948385 (c.-5304G>A) and rs9913583 (c.-86C>A), which are located in the promoter region or 5′-untranslated region of PEDF, the pooled ORs were not statistically significant in AMD in the allelic (Table 3 and Figs. 3, 4, 5) or other genetic models (Supplementary Table S1). The gene discussed is SERPINF1; the disease is age-related macular degeneration.