Upon identifying a lack of association of the PEDF SNPs with AMD and PCV, we searched for possible association of PEDF with other ophthalmic and non-ophthalmic diseases with a view to better understand the role of PEDF. Previously, based on linkage analysis, Koenekoop et al. suggested PEDF as a causative gene for Leber's congenital amaurosis63. The gene discussed is SERPINF1; the disease is age-related macular degeneration.