MAPT and Alzheimer disease: The 3 × Tg-AD mice (homozygous for the PS1 mutation, APPSwe and tauP301L transgenes) show learning and memory deficits in MWM or contextual fear conditioning, formation of the extracellular Aβ plaques in the cerebral cortex and tau pathology at 6 m old32, and tangle pathology was advanced by 20 m33.