BHLHE40 and esophageal cancer: Two-way ANOVA analysis revealed a statistically significant interaction between genotype and time point [F(1,19) = 5.89; P < 0.05] for basic helix-loop-helix family, member e40 (Bhlhe40) also known as deleted in esophageal cancer 1 (Dec1) (Fig. 3a), without significant main effect.