Extending the findings of a recent meta-analysis by Anand et al,9 we through a larger Mendelian randomization meta-analysis of the data from 25 articles and on 91070 participants, found that reduced circulating HDL-C might be a potentially causal risk factor for the development of overall cancer in Asians by using APOE gene ε2/ε3/ε4 polymorphism as a surrogate marker. The gene discussed is APOE; the disease is cancer.