Increased expression of genes encoding an enzyme that hydrolyses triglycerides to facilitate the uptake of free fatty acids (LPL) (Mead et al, 2002), a membrane translocase that promotes FA entry into the cell (CD36), an enzyme that catalyses the conversion of FA to AcylCoA (ACSF2), and the rate-limiting enzyme for β-oxidation responsible for the FA transfer into the mitochondria (CPT-1B) (McGarry et al, 1983) in asymptomatic SOD1G86R mice suggests that fatty acids intake is increased into glycolytic muscle tissue when ALS occurs. This evidence concerns the gene LPL and amyotrophic lateral sclerosis.