ACSF2 and amyotrophic lateral sclerosis: Increased expression of genes encoding an enzyme that hydrolyses triglycerides to facilitate the uptake of free fatty acids (LPL) (Mead et al, 2002), a membrane translocase that promotes FA entry into the cell (CD36), an enzyme that catalyses the conversion of FA to AcylCoA (ACSF2), and the rate-limiting enzyme for β-oxidation responsible for the FA transfer into the mitochondria (CPT-1B) (McGarry et al, 1983) in asymptomatic SOD1G86R mice suggests that fatty acids intake is increased into glycolytic muscle tissue when ALS occurs.