ERBB2 and neoplasm: As shown in Fig. 6(b) and 6(d), only the targeted tumor areas exhibited fluorescence signals from the FAF610-SERSRITC/FITC dots (represented by blue color in the FRES images or red color in the confocal laser scanning microscopy images), thus indicating that the antibody-conjugated F-SERS dots were specifically bound to the HER2 and EGFR expressing tumor tissues.