INS and polycystic ovary syndrome: IR with hyperinsulinaemia is common in lean and obese women with PCOS; this condition is associated with women's reproductive abnormalities, including fetal macrosomia, polyhydramnios, operative delivery, high perinatal mortality and neonatal metabolic complications.3 Approximately 40% of women with PCOS exhibit glucose intolerance.4 The optimal therapy for PCOS should improve insulin sensitivity through lifestyle and drug intervention.