STEAP4 and atherosclerosis: Additionally, because high glucose (HG) increases IL6 only in Steap4-deficient [but not wild-type (WT)] adipocytes 14 while overexpressing Steap4 suppresses atherosclerosis in diabetic mice 18, we hypothesize that Steap4 overexpression may attenuate HG or S100B-induced effects in mesangial cells.