AKR1C1 and prostate neoplasm: Data presented here shows (i) expression of AKR1C1 decreases in human prostate tumors, (ii) 5α-DHT enhances AKR1C1 expression; (iii) both 3β-Adiol and ERβ suppress c-FLIP activation in DU145 and PC-3 cells but not in LNCaP cells.