MMP9 and neoplasm: In this study, we found the upregulation of VEGF, HIF-1α, IL-6, MMP-2 and MMP-9 in tumor xenografts derived from OCT4B-expressing cells, suggesting that OCT4B increases endothelial cell migration, vascular sprouting in vitro, and vasculature formation in cervical cancer to promote tumor growth, relapse and metastasis.