POU5F1 and neoplasm: Several target genes of miR-145, including mucin 1 (MUC1), DNA Fragmentation Factor-45 (DFF45), catenin δ-1, histone deacetylase 2 (HDAC2), v-ets avian erythroblastosis virus e26 oncogene homolog (ERG), N-cadherin (CDH2), and POU class 5 homeobox 1 (OCT4), have been verified [22–28], and on the basis of these observations, miR-145 has been acknowledged as a tumor suppressor.