The incidence of hypoglycemia in the Ins+Sita group was significantly reduced during the study compared with that in the Insulin group (0.4 ± 1.3 vs. 0.8 ± 1.3 times/person∙month, difference between the groups; -0.3 times/ person∙month, 95% CI, -0.6 to -0.1, P <0.001, Fig. 3d and S1 Fig). This evidence concerns the gene INS and Hypoglycemia.