INS and diabetes mellitus: Multivariate regression analysis including age, sex, duration of diabetes, BMI, insulin dose, baseline HbA1c and baseline fasting CPR showed insulin dose, baseline HbA1c and baseline fasting CPR to be independent variables predicting ΔHbA1c in the Ins+Sita group (standardized coefficients; 0.54, -0.57 and -0.44, P = 0.01, 0.002 and 0.04, respectively).