AFP and hepatocellular carcinoma: After the multivariate analysis, the association between high HCC recurrence rate and the following factors were also revealed: vascular invasion (adjusted HR = 2.534 [1.369, 4.689], p = 0.003), preoperative AFP level (>400 ng/ml) (adjusted HR = 2.878 [1.667, 4.966], p<0.001), diameter of largest tumor (>5 cm) (adjusted HR = 4.629 [2.407, 8.901], p<0.001) (Table 5).