In the livers of patients with cirrhosis caused by HCV, Novo et al. found that activated HSCs are resistant to most pro-apoptotic stimuli, including NGF neurotrophin due to overexpression of the Bcl-2 anti-apoptotic marker present in liver tissue; this characteristic may play a key role in the progression of fibrosis in chronic liver diseases [31]. The gene discussed is BCL2; the disease is Cirrhosis.