Furthermore, along with increasing necroinflammatory and fibrotic severity, serum GP73 increased with the progression of chronic hepatitis B. Serum GP73 levels were 53.15 ± 22.79 ng/mL in HBV-C, 110.19 ± 66.91 ng/mL in CHB, 195.01 ± 104.22 ng/mL in HCC, and 225.71 ± 99.37 ng/mL in LC. This evidence concerns the gene GOLM1 and laryngotracheoesophageal cleft.