GOLM1 and hepatocellular carcinoma: In addition, GP73 protein may consist of several subtypes, some of which may show higher HCC detection specificity.37 A number of challenges remain before GP73 can be used as a biomarker for HCC, including inconsistent specificity, insufficient sensitivity, and nonsatisfactory value for early diagnosis of HCC.38,39 Therefore, further evaluation should be carried out in large multicenter-based cohorts.