Because antiviral treatment rarely cures HBV infection, the primary goals of antiviral therapy are as follows: first, the suppression of HBV replication; second, the prevention of liver disease progression to cirrhosis, decompensated cirrhosis, or HCC; and third, the delay of end-stage liver disease.4,6 Alanine aminotransferase (ALT) blood concentration is an important index used to evaluate liver injury and decide if chronic HBV patients should receive antiviral therapy. This evidence concerns the gene GPT and hepatocellular carcinoma.