GPT and Cirrhosis: Because antiviral treatment rarely cures HBV infection, the primary goals of antiviral therapy are as follows: first, the suppression of HBV replication; second, the prevention of liver disease progression to cirrhosis, decompensated cirrhosis, or HCC; and third, the delay of end-stage liver disease.4,6 Alanine aminotransferase (ALT) blood concentration is an important index used to evaluate liver injury and decide if chronic HBV patients should receive antiviral therapy.