Endoscopic ultrasonography has a reported sensitivity of 87% to 92%, although it is largely operator dependent and its sensitivity is lower for insulinomas in the tail of the pancreas or extrapancreatic.11 Angiography combined with arterial stimulation venous sampling, using calcium as the insulin secretagogue, is probably the most sensitive available diagnostic technique, with an accuracy ranging from 94% to 100%.12 Manual palpation of the pancreas by an experienced surgeon and ultrasonography are both sensitive methods for the intraoperative detection of the site of insulinomas. The gene discussed is INS; the disease is pancreatic insulinoma.