Thus, vaccinated IL-4Rα-/- mice fail to expel worms and actually incurred higher egg burdens than wild-type controls (Fig. 4A, S3A Fig), despite generating HES-specific IgG1 responses similar in titre to those seen in B6 primary infection (S3B Fig), and equivalent in specificity to immunised wild-type mice (S3C Fig). The gene discussed is IL4R; the disease is infection.