Furthermore, the frequencies of genotypes carrying the low frequency A and C alleles in the rs1048719 (GM2A gene exon 1) and rs2075783 loci (GM2A intron), respectively, were significantly higher in the NEC group compared with the control group (χ2=4.316, P=0.038; and χ2=13.717, P=0.000, respectively). This evidence concerns the gene GM2A and necrotizing enterocolitis.