HNF4A and malignant colon neoplasm: More recently, Chellappa, et al. investigated the relationship between Src kinase and HNF4α in human colon cancer and also found that three functional variants harbored in HNF4α (rs6093980, rs6031602 and rs1063239) could increase phosphorylation by Src kinase and decrease the stability of HNF4α protein [19].