Finally, exposure to purmorphamine, cyclopamine and Gant 61 did not significantly affect the paracrine immunosuppressive properties of C-S and C-NS fibroblasts while Hh antagonists significantly improved the ability of COPD cells to inhibit the proliferation of CD3/CD28 stimulated PBMC (Fig 6D). The gene discussed is CD28; the disease is chronic obstructive pulmonary disease.