Ob/ob mice are congenic for the mutation in the OB gene resulting in loss of leptin hormone and exhibit symptoms of MetS including visceral obesity, a diabetes-like syndrome of hyperglycemia, elevated plasma insulin, and increased circulating LDL and VLDL cholesterol levels (http://jaxmice.jax.org/strain/000632.html#pheno). The gene discussed is LEP; the disease is Hyperglycemia.