PML and acute promyelocytic leukemia: The presence of t(15;17)(q22;q21) with the promyelocytic leukemia-retinoic acid receptor alpha (PML-RARa) fusion gene is regarded as the hallmark of acute promyelocytic leukemia (APL), characterized by a translocation involving the fusion of the promyelocytic leukemia (PML) gene at 15q22 with retinoic acid receptor alpha (RARa) gene at 17q21 [1–3].