Table I shows DEGs with a degree >60 in the constructed PPI network, including β-catenin (CTNNB1, 135), SHC-transforming protein 1 (SHC1, 117), RAC-α serine/thre-onine-protein kinase (AKT1, 117), caveolin 1 (CAV1, 73) and filamin A (FLNA, 63). CTNNB1 and CAV1 were significantly downregulated in the samples from the patients with osteoporosis, while the other three genes were upregulated (Table I). The gene discussed is SHC1; the disease is osteoporosis.