Table I shows DEGs with a degree >60 in the constructed PPI network, including β-catenin (CTNNB1, 135), SHC-transforming protein 1 (SHC1, 117), RAC-α serine/thre-onine-protein kinase (AKT1, 117), caveolin 1 (CAV1, 73) and filamin A (FLNA, 63). CTNNB1 and CAV1 were significantly downregulated in the samples from the patients with osteoporosis, while the other three genes were upregulated (Table I). This evidence concerns the gene FLNA and osteoporosis.