NFE2L2 and obesity due to melanocortin 4 receptor deficiency: These results indicated that Pic was protective against PA-induced endothelial dysfunction by inducing the Nrf2-dependent expression of HO-1, suggesting a potential strategy of targeting the expression of HO-1 by Pic for endothelial protection in the presence of high levels of PA, including that in obesity, diabetes and other metabolic inflammatory diseases.