Bile acids inducing cancer cell proliferation via epidermal growth factor receptors (EGFR), Farnesoid X receptors (FXR), sphingosine 1-phosphate receptor 2 (S1PR2), and G-protein-coupled bile acid receptor 1 (TGR5) have been associated with many types of cancer such as colon, liver and uterus (4–7). The gene discussed is GPBAR1; the disease is cancer.