TRIM25 and Renal insufficiency: The 1.6-Mb microdeletion identified in Family F13 is among the smallest ones associated with NOG-SSD, resulting in a single copy deletion in thirteen genes—TMEM100, PCTP, ANKFN1, C17orf67, DGKE, MTVR2, MIR3614, TRIM25, COIL, SCPEP1, RNF126P1, AKAP1 and NOG. Of the twelve genes other than NOG, only DGKE is associated with human disorders, as the recessive loss-of-function mutations in DGKE may result in atypical hemolytic-uremic syndrome characterized with microangiopathic hemolytic anemia, thrombocytopenia and renal failure [12,13].