In the present study, leukemia HL-60 cells were treated with the HDACi 5-aza-2′-deoxycytidine (5-Aza-CdR) and/or the DNMTi suberoylanilide hydroxamic acid (SAHA) and then stimulated by IFN-γ to explore their effect on CIITA methylation and the resulting MHC class II expression. Here, CIITA is linked to leukemia.