Here we retrospectively conducted a clinical pharmaceutical study on a cohort of normogonadotropic infertile patients addressed to long GnRH-agonist protocol with serum LH concentration ranging from 0.5 IU/L to 1.5 IU/L on stimulation days 6–8 to investigate the effect of purified HMG supplement during ovarian stimulation. Here, GNRH1 is linked to Infertility.