It was noted that the p-AKT(Ser473) and p-mTOR(Ser2448) protein levels were also significantly markedly elevated in the cancerous HCC patients with AFP(+) tissues (Figures1B), demonstrateding that AKT/mTOR signaling pathway activation was involved in pathological progressing pathogenesis of HCC patients with AFP(+). The gene discussed is AKT1; the disease is hepatocellular carcinoma.