The levels of AFP, CXCR4, phospho-AKT(Ser473)[p-AKT(Ser473)], and phospho-mTOR(Ser288 4) [p-mTOR(Ser2448)] proteins in the specimens from the tissues of normal liver, HCC patients with AFP(−), and HCC patients with AFP(+) and its pericarcinoma were evaluated by Western blotting. The gene discussed is CXCR4; the disease is hepatocellular carcinoma.