MTOR and hepatocellular carcinoma: Reduced AFP in the AFP-siRNA transfected, ChIP results indicated that human hepatoma PLC/PRF/5 cells were transfected with AFP-siRNA vectors led to an apparent reduction of binding of p-mTOR(Ser2448) to the promoter elements in the 5′-flanking region of the CXCR4 gene compared to the input(Figure 6A).