Consistent with the IHC results, high AFP and CXCR4 expressions were emerged seen in the tumor HCC tissues with AFP(+) compared to the adjacent non-cancerous liver tissues, HCC patients with AFP(−), and normal liver tissues(Figure1B), implicated suggesting that CXCR4 overexpression is closely correlated to HCC patients with AFP(+). This evidence concerns the gene AFP and hepatocellular carcinoma.