APOE and metabolic syndrome: Out of the 15 loci that are associated with both lipids and glucose-related traits independently, 8 (CETP, MLXIPL, PLTP, GCKR, APOB, APOE-C1-C2, CYP7A1, and TIMD4) did exert an opposite allelic effect on dyslipidemia and glucose traits [28].