Since cblb-deficient mice are largely protected from tumor formation (72, 73) and adoptive transfer of cblb negative or transiently silenced CD8+ T cells in combination with DC vaccination delays tumor growth in several mouse models (74, 122) it was interesting to know whether loss of Cbl-b in DCs also contributes to tumor resistance of cblb knockout animals (119). This evidence concerns the gene CD8A and neoplasm.