About 100% of cblb-deficient p14/Rip-gp mice versus <50% of cblb+/+ p14/Rip-gp mice developed diabetes when infected with LCMV expressing the low-affinity ligand LF6, accompanied by enhanced T cell proliferation and enhanced cytotoxic T-lymphocyte function in cblb-deficient mice (65). This evidence concerns the gene CBLB and diabetes mellitus.