CBLB and Sepsis: In addition, production of TNF-α and MIP-1α after LPS stimulation was higher in cblb-deficient animals, whereas other cytokines such as RANTES and IL-6 remained unchanged but showed Cbl-b dependent regulation when polymicrobial sepsis was induced after cecal ligation and puncture (127), or after cardiotoxin-induced muscle damage (133).