PRRT2 and early-onset autosomal dominant Alzheimer disease: Some other protective effects attributed to PKC have been reviewed by Etcheberrigaray et al. [112] with the suggestive title “Therapeutic Effects of PKC Activators in Alzheimer's Disease Transgenic Mice.” Indeed, opposite to the idea that the activity of PKC is accompanied by a chain of deleterious effects during neurodegeneration, rather the inactivity of PKC is the real threat for the progression of AD [12].