AR and Familial prostate cancer: The polyphenols also inhibited the expression of genes for key androgen-synthesizing enzymes and androgen receptors, suggesting that the pomegranate polyphenols (mainly the oligomeric punicalagin and the monomeric ellagic acid) affect androgen-independent prostate cancer cells and the subset of human prostate cancer cells where the androgen receptor is upregulated [4, 14].