SNCA and Parkinson disease: Hypomethylation of intron 1 of the α-synuclein (SNCA) gene might be relevant for PD pathogenesis, inducing an increased expression of α-synuclein in the substantia nigra of PD patients and possibly contributing to the Lewy Body formation (Jowaed et al., 2010; Matsumoto et al., 2010; Lu et al., 2013).