Till now the studies performed on PARK2 mutant fibroblasts in order to explore the impact of Parkin on mitochondrial functionality, have remain elusive (Mortiboys et al., 2008; Grünewald et al., 2010; Pacelli et al., 2011; van der Merwe et al., 2014); however these reports highlighted how fibroblasts derived from PD patients may be a reliable model system to study mitochondrial dysfunction. The gene discussed is PRKN; the disease is Parkinson disease.