As previously reported, a candidate screen for genetic association to pulmonary AVMs in HHT patients showed that PTPN14 within the TGFBM2 locus showed the strongest genetic association to pulmonary AVM incidence in both HHT1 and HHT2 mutation carriers (Benzinou et al., 2012). This evidence concerns the gene PTPN14 and hereditary hemorrhagic telangiectasia.