Furthermore, RGS1, CCL3, and SOCS1 were connected to sepsis in animal studies (Panetta et al., 1999; Takahashi et al., 2002; Grutkoski et al., 2003), while for CTSD increased expression levels were observed in mice with induced septic shock (Yoo et al., 2013). This evidence concerns the gene RGS1 and Shock.