The patient described by Compta et al. (2009) with clinical features of PD and VH and widespread phosphorylated tau deposits consistent with PSP, included severe tau pathology in the hippocampus and amygdala in the absence of LBs, therefore leading to the suggestion that the location of pathological lesions in the brain is the most important factor determining VH (Compta et al., 2009). This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.