Another unexpected commonality between neurodegenerative diseases and epilepsy may be a defect of autophagy (Wong, 2013; Lipton and Sahin, 2014) due to dysfunction of the mammalian or mechanistic target of rapamycin (mTOR) signaling pathway (Wong, 2013; Lipton and Sahin, 2014). This evidence concerns the gene MTOR and neurodegenerative disease.