HSPA1A and obesity due to melanocortin 4 receptor deficiency: It has been reported that iHSP72 mRNA levels are decreased in skeletal muscle of T2DM patients which is correlated with the “status” of insulin resistance [65], whereas heat shock-like therapies (i.e., whole body warming, transgenic overexpression, or pharmacological mechanisms to elevate HSPA1A protein expression) protect against high-fat-diet- and obesity-induced hyperglycemia, hyperinsulinemia, glucose intolerance, and insulin resistance [14, 65, 66].