NPPB and heart failure: Squire and colleagues reported that a panel of four miRNAs (miR-16, miR-27a, miR-101, miR-150) improved the prediction of left ventricle (LV) contractility six months after AMI, in a multivariable model that included Nt-proBNP, an established biomarker of heart failure.24 These findings built upon their previous demonstration that reduced levels of miR-150 levels were associated with increased LV remodelling after ST segment elevation myocardial infarction (STEMI),w34 and herald promise in the use of miRNAs, or panels of miRNAs, as diagnostic and prognostic predictors of heart failure.