We conclude that the combination of RAF and JNK inhibition (or JUN depletion) increases apoptosis in some vemurafenib-resistant cell lines to a level normally observed in sensitive cells, implying that the up-regulation of JNK/c-Jun in melanoma cells following vemurafenib exposure decreases cell killing and that the combination of RAF and JNK inhibitors may have therapeutic potential. The gene discussed is MAPK8; the disease is melanoma.