CDK1 and familial pancreatic carcinoma: For example, a CDK1-dependent pathway has been found to affect how stress hormones mediate drug resistance in human breast cancer cells24 In addition, the overexpression of HMGA1 has been reported to enhance oncogenetic miR-222 transcriptional activity in NSCLC25 and to promote chemoresistance to gemcitabine in pancreatic cancer cells26.