IFNB1 and myeloid sarcoma: Further following this explanatory model of a spatially differential sVCAM-1 release in untreated active versus IFN-β-treated MS patients, an inverse correlation between sVCAM-1 serum levels and Gd-enhancing MRI brain lesions in IFN-β-treated MS patients could then be explained by a predominant therapeutic effect of sVCAM-1-triggered VLA-4 downregulation on PBMC via ligand–receptor interaction as previously demonstrated [31].